منابع مشابه
Focal adhesions
What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
متن کاملFocal adhesions come unstuck
Focal adhesions come unstuck C rawling cells pick up after themselves before moving on. Ezratty et al. (1) show that cells use the endocytic protein clathrin to reabsorb the integrin receptors that attach them to surfaces, instead of simply leaving the molecules behind. Cells on the go gain traction by forming focal adhesions (FAs), temporary attachments to the surface. But if they can't break ...
متن کاملLate endosomes uproot focal adhesions
Keeping DNA replication below PAR T he polarity proteins PAR-4 and PAR-1 delay cell division in early C. elegans embryos by inhibiting DNA repli-cation, Benkemoun et al. reveal. Cells must divide at the right time during development. This is true from the get-go in C. elegans embryos where, at the two-cell stage, the anterior blastomere divides while its smaller, posterior sister is still in S ...
متن کاملFocal adhesions: what's new inside.
The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression. These complexes are heterogeneous and dynamic structures that are apparent targets of regulatory signals that control the f...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1999
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(99)80272-3